Browsing by Discipline
Now showing items 1-20 of 56
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18F Radiolabeling of epidermal growth factor receptor-tyrosine kinase inhibitor anti-cancer drugs for therapeutic outcome studies
(2023)Epidermal growth factor receptor is a transmembrane protein with tyrosine kinase activity that plays a vital role in the proliferation, differentiation, and survival of normal cells. When mutations in this protein occur, ... -
Amorphous Selenium (a-Se) and its Compounds: Photo-induced Metastability and Application in a Novel Gamma Camera
(2016)Despite the large number of successful commercial applications of chalcogenide glasses (ChGs) ranging from memory devices to photonics and medical imaging detectors, the understanding of a fundamental property – ... -
Application of flow-through sold-phase-synthesis to the fluorescent labeling of amines with carboxylic and funtionalized bodipy dyes
(2024)The use of fluorophores for the labelling of biomolecules in living cells has become a key method for understanding processes in cellular biology. Synthetic fluorescent molecules can be introduced non-specifically to ... -
Assessing and characterizing the inductive effect through silicon containing backbones and on silicon reactivity
(2014-01-22)This thesis describes a study of the inductive effect in derivatives of bicyclo[1.1.1.]pentane; chosen because it eliminates any possibility of conjugation between the substituent and probe, and keeps the steric effect ... -
Biological studies of muramyl dipeptide analogues as potential ligands for NOD2 receptor
(2023)The human body’s survival against various foreign disease-causing organisms solely depends on the protection provided by our body's immune system. Our body's complex yet effective immune system comprises cells, molecules ... -
C-N bond formation employing palladium and nickel precatalysts containing anionic phosphinobenzimidazole ligands
(2016)In this investigation, the catalytic utility of anionic, phosphinobenzimidzoles [Li(THF)2][1a] and [Li(THF)4][1b] in effecting the Buchwald-Hartwig amination reaction was examined. Specifically, the coordination chemistry ... -
Computational tools for the high-throughput identification of protein-targeted drugs and probes
(2015-08-04)This thesis is comprised of three projects that are driven by a common theme, which is the use of computational tools in aiding molecular probe and drug design. In the first project, the feasibility of using molecular ... -
Constructing two-dimensional molecular networks on metal and semiconducting surfaces : a scanning tunneling microscopy study
(2019)The synthesis of two-dimensional organic nanostructures on metal and semiconducting surfaces is studied under ultra-high vacuum (UHV) conditions. Three halogenated organic molecules are investigated using scanning tunneling ... -
Coordination chemistry of bithiazole ligands: a comparative study of the 2,2’ and 4,4’ isomers
(2019)The bithiazole ring system consists of two thiazole (C3NS) aromatic rings. There are many regioisomers but two of potential interest for coordination chemistry are the 2,2’-bis(1,3-thiazole) and the 4,4’-bis(1,3-thiazole), ... -
Copolymerization of pretreated kraft lignin and acrylic acid to produce flocculants for suspension and solution systems
(2017)The presence of dyes in the wastewater of textile industry poses a number of environmental concerns due to their toxic nature and the removal of dyes from the wastewater is a major challenge nowadays. Synthetic polymers ... -
Cross-coupling reactions: synthesis and photoactivity of enediynes
(2015-02-02)The syntheses of a number of photoactive enediynes using the Sonogashira Coupling reaction are described. Alkynes with different characteristics were coupled to 2-bromoiodobenzene to yield the desired drugs. The enediyne’s ... -
Design and electrochemical study of Pd-based nanostructures for hydrogen economy
(2017)Hydrogen storage remains one of the most challenging prerequisites to overcome toward the realization of a hydrogen based economy. The use of hydrogen as an energy carrier for fuel cell applications has been limited by the ... -
Design and synthesis of small molecule ligands targeting protease-activated receptor 2 as potential diagnostic and therapeutic agents
(2021)Positron emission tomography (PET) imaging requires radionuclides (positron-emitters) labeled molecules (tracers) to image biochemical and physiological processes in vivo and helps diagnose diseases noninvasively. The ... -
The design of Zr metal-organic frameworks in the detection and neutralization of organophosphorus based nerve agents and pesticides
(2022)Organophosphates are ubiquitous in uses ranging from chemical warfare agents (CWA’s) to detergents. In between these two extreme uses lie organophosphorus-based agrichemicals, primarily pesticides, which are applied in ... -
The design, synthesis and enzymatic evaluation of aminocyclitol inhibitors of glucocerebrosidase
(2014-01-22)Gaucher disease, the most common lysosomal storage disorder, is caused by mutations in the GBA gene which codes for the enzyme glucocerebrosidase (GCase) resulting in its deficiency. GCase deficiency results in the ... -
Design, synthesis, and evaluation of novel lysophosphatidic acid receptor-targeting small molecules as therapeutic and diagnostic agents
(2023)Breast cancer has the highest incidence rate of all cancers among Canadian women and accounts for nearly 14% of all cancer-related deaths in Canada. This type of cancer is often detected using medical imaging modalities ... -
Development of an 18F radiolabeling method using solid phase chemistry
(2023)New radiotracers are constantly being developed to expand the clinical applications of positron emission tomography (PET). One of the challenges in the development of PET tracers is the incorporation of a positron emitting ... -
The development of an in-situ ATR-FTIR technique for the study of nanomaterials
(2009)The Fourier Transform Infrared Spectroscopy technique utilizes a short acquisition time and high sensitivity to function as a strong analytical tool in electrochemical studies. This work will focus on the development of ... -
Development of graphite based nanomaterials for green chemistry applications
(2017)Graphite is a valuable natural resource and useful carbon allotrope that has been explored for various applications. Graphene is a two-dimensional (2D) transparent material, which is the strongest, thinnest, and most ... -
The development of molecular probes for the in vitro and in vivo study of glucocerebrosidase
(2017)Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases in the world. Despite its prevalence, the disease is difficult to diagnose early with the vast majority of individuals already having significant ...
